Gangtok, 19 Nov:
Lecturer, Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences [SMIMS], Rinchen Doma Bhutia, successfully defended her Ph.D. thesis on 12 Nov under the guidance of Head of the Department of Biochemistry, SMIMS, Professor [Dr] TA Singh, Chief Operating Officer, Professor [Dr] Mingma L Sherpa, and Head of Department of Medicine, SMIMS, Professor Bidita Khandelwal.
A press release issued by Sikkim Manipal University informs that Ms Bhutia’s Ph.D. research topic was “Study of blood oxidation products of DNA, lipid and protein in and among individuals progressing towards Metabolic Syndrome” which was funded by the Indian Council of Medical Research [ICMR].
National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases [CVD] and Stroke has reported Sikkim to have the highest percent of Diabetes [DM] and Hypertension in the country in 2013.
Sikkim still leads in the prevalence of hypertension which increases the risk of heart disease and stroke. A common precursor of the duo [DM and HTN] has been termed the Metabolic Syndrome [MetS]. A person with MetS is twice as likely to die from and three times more likely to have a heart attack or stroke which is indeed an early warning sign.
MetS is diagnosed when a person has any three of the following risk factors including a large waist circumference, elevated blood pressure, raised fasting blood sugar and dyslipidemia. It promotes cardiovascular risks by several mechanism including Oxidative stress [OS].
This study was conducted to understand the relative damages caused to DNA, lipid and protein molecule as a result of the reductive stress turned oxidative stress in patients [≥ 20 years of age] diagnosed with and without MetS. The study demonstrated that the occurrence of the syndrome increased with increasing age and was found more common in the female participants.
Daughter of Pema ChodenBhutia and Late Norgyal Bhutia from Sang, East Sikkim, Ms Bhutia did her schooling from Paljor Namgyal Girls Senior Secondary School, Gangtok and later her B.Sc. in Biochemistry from North Bengal University and M.Sc., Biochemistry from SMIMS.
She received 2nd Prize for an Oral presentation for the article titled “Oxidative Stress in MetS and DNA strand break” at Manipal Research Colloquium 2017, Manipal University, Udupii, Karnataka. She has a number of research papers and publications to her credit.
Ms Bhutia has been recommended for award of degree by the Board of Examiners of Sikkim Manipal University. The Doctor of Philosophy will be awarded to her during the forthcoming Convocation of Sikkim Manipal University [SMU].